OS X Maintenance - how to keep the system clean?

OS X Maintenance - how to keep the system clean? I'm a .NET developer and a long time Windows user. Recently I've been working a little bit on OS X Leopard, trying to learn iPhone development.
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Guest [Entry]

"I actually never do any maintenance directly since there are quite a few scripts that run weekly and monthly for this purpose.

However I do run OnyX every once in a while to just make sure everything still works fine."