How to monitor the system file real time?

How to monitor the system file real time? As we know, virus and malware will change or replace the important files on our system,is there any way to know it when this change happened?it is for windows 7,by the way.
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bert [Entry]

"If you know the location of the file you want to modify www.FolderTrack.com may be a good solution.
It is free if you use discount code: bos.

This depends on the virus though.

Disclaimer I wrote FolderTrack"