Can I hide or lock one drive for Acronis backups only?

Can I hide or lock one drive for Acronis backups only? I have a 500 GB hard disk drive. I am using Acronis to have backups over there.
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Guest [Entry]

"You can mount the drive to an NTFS folder instead of a drive letter, as described here:
http://support.microsoft.com/kb/307889

The folder would be visible in Explorer, but you wouldn't see it listed as another drive."